The European Society of Human Reproduction and Embryology (ESHRE) has introduced the Female Reproductive Genetics Initiative (FeRGI) to bolster the diagnosis and treatment of infertility through genetic insights. Led by the Special Interest Group (SIG) Reproductive Genetics, FeRGI aims to bridge genetic research with clinical practice, equipping healthcare professionals with essential tools and knowledge.
In the past decade and a half, significant strides have been made in identifying non-syndromic infertility genes for both men and women. FeRGI intends to leverage these advancements by translating genetic findings into practical applications, particularly in diagnostic methodologies. The initiative’s core mission is to empower reproductive medicine specialists with the expertise needed to integrate genetic insights effectively.
FeRGI brings together a multidisciplinary team comprising experts in medically assisted reproduction (MAR), encompassing both fundamental researchers and clinical practitioners. Guided by a systematic review and evidence assessment of gene-disease relationships in female infertility, published in Human Reproduction Update by Van Der Kelen et al. (2023), the initiative ensures comprehensive oversight through its steering committee from the Reproductive Genetics SIG.
Central to FeRGI’s efforts is the development of an interactive web platform providing comprehensive information on genes associated with female infertility and their phenotypic manifestations. The platform will also facilitate ongoing updates and collaboration by allowing researchers to submit newly identified gene variants.
Beyond compiling data, FeRGI serves as a global hub for collaboration and knowledge exchange. Hosted by ESHRE and the Reproductive Genetics SIG, FeRGI will organize educational initiatives such as scientific symposiums, webinars, workshops, and online programs. These activities aim to foster international cooperation among experts, young specialists, scientists, PhD students, and post-doctoral researchers, promoting advancements in female infertility genetics and their clinical application.
FeRGI is also tasked with developing guidelines and recommendations for best practices, ensuring that technological innovations are implemented ethically. By deepening understanding of the genetic underpinnings of female infertility, FeRGI seeks to enhance diagnostic accuracy, treatment outcomes, and fertility preservation options for patients and their families.
Stéphane Viville, a key contributor to FeRGI, emphasizes its mission to empower reproductive medicine practitioners with the necessary resources and expertise to advance diagnostics and enhance professional capabilities in female infertility genetics.
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